Dianne K. Newman
Gordon M. Binder/Amgen Professor of Biology and Geobiology; Merkin Institute Professor
B.A., Stanford University, 1993; Ph.D., Massachusetts Institute of Technology, 1997. Clare Booth Luce Assistant Professor, Caltech, 2000-05; Associate Professor, 2005-06; Professor, 2006-16; Binder/Amgen Professor, 2016-; Davis Leadership Chair, 2017-20; Merkin Institute Professor, 2024-; HHMI Investigator, 2005-16; Executive Officer, 2017-23.
Research Summary
Bioenergetics and cell biology of metabolically diverse, genetically-tractable bacteria. Biofilm survival physiology in the context of human chronic infections and crop rhizospheres.
Research Options
Environmental Science and Engineering;
Geobiology;
Research Areas
Environmental Geochemistry;
Isotope Biogeochemistry;
Molecular Microbial Ecology;
Publications
- Squyres, Georgia R;Newman, Dianne (2024) Biofilms as more than the sum of their parts: lessons from developmental biologyCurrent Opinion in Microbiology
- Ciemniecki, John A.;Ho, Chia-Lun et al. (2024) Mechanistic study of a low-power bacterial maintenance state using high-throughput electrochemistryCell
- Horak, Richard D.;Ciemniecki, John A. et al. (2024) Bioenergetic suppression by redox-active metabolites promotes antibiotic tolerance in Pseudomonas aeruginosaProceedings of the National Academy of Sciences
- Flamholz, Avi I.;Goldford, Joshua E. et al. (2024) Annotation-free prediction of microbial dioxygen utilizationmSystems
- Zhang, Oumeng;Alcalde, Reinaldo E. et al. (2024) Investigating 3D microbial community dynamics of the rhizosphere using quantitative phase and fluorescence microscopyProceedings of the National Academy of Sciences
- Wang, Renée Z.;Lonergan, Zachery R. et al. (2024) Widespread detoxifying NO reductases impart a distinct isotopic fingerprint on N₂O under anoxiaProceedings of the National Academy of Sciences
- Kim, Jane H.;Dong, Julianna et al. (2024) Pseudomonas aeruginosa Activates Quorum Sensing, Antioxidant Enzymes and Type VI Secretion in Response to Oxidative Stress to Initiate Biofilm Formation and Wound ChronicityAntioxidants
- Tsypin, Lev M. Z.;Saunders, Scott H. et al. (2024) Genetically dissecting the electron transport chain of a soil bacterium reveals a generalizable mechanism for biological phenazine-1-carboxylic acid oxidationPLOS Genetics
- Magkiriadou, Sofia;Stepp, Willi L. et al. (2024) Polyphosphate affects cytoplasmic and chromosomal dynamics in nitrogen-starved Pseudomonas aeruginosaProceedings of the National Academy of Sciences
- Zhang, Irene H.;Borer, Benedict et al. (2024) Uncultivated DPANN archaea are ubiquitous inhabitants of global oxygen-deficient zones with diverse metabolic potentialmBio
- Flamholz, Avi I.;Goyal, Akshit et al. (2024) The proteome is a terminal electron acceptor
- Kim, Jane H.;Spero, Melanie et al. (2024) Targeting Anaerobic Respiration in Pseudomonas aeruginosa with Chlorate Improves Healing of Chronic WoundsAdvances in Wound Care
- Larsson, Elin M.;Murray, Richard M. et al. (2024) Engineering the Soil Bacterium Pseudomonas synxantha 2–79 into a Ratiometric Bioreporter for Phosphorus LimitationACS Synthetic Biology
- Wang, Renée Z.;Lonergan, Zachery R. et al. (2023) Widespread detoxifying NO reductases impart a distinct isotopic fingerprint on N₂O under anoxia
- Thalhammer, Korbinian O.;Newman, Dianne K. (2023) A phenazine-inspired framework for identifying biological functions of microbial redox-active metabolitesCurrent Opinion in Chemical Biology
- Jiménez Otero, Fernanda;Newman, Dianne K. et al. (2023) Pyocyanin-dependent electrochemical inhibition of Pseudomonas aeruginosa biofilms is synergistic with antibiotic treatmentmBio
- Ciemniecki, John A.;Newman, Dianne K. (2023) NADH dehydrogenases are the predominant phenazine reductases in the electron transport chain of Pseudomonas aeruginosaMolecular Microbiology
- McRose, Darcy L.;Liang, Jinyang et al. (2023) The chemical ecology of coumarins and phenazines affects iron acquisition by pseudomonadsProceedings of the National Academy of Sciences of the United States of America
- Flamholz, Avi I.;Saccomano, Samuel et al. (2022) Optical O₂ Sensors Also Respond to Redox Active Molecules Commonly Secreted by BacteriamBio
- Wilbert, Steven A.;Newman, Dianne K. (2022) The contrasting roles of nitric oxide drive microbial community organization as a function of oxygen presenceCurrent Biology
- Spero, Melanie A.;Jones, Jeff et al. (2022) Mechanisms of chlorate toxicity and resistance in Pseudomonas aeruginosaMolecular Microbiology
- Jiménez Otero, Fernanda;Newman, Dianne K. et al. (2022) Electrochemical disruption of extracellular electron transfer inhibits Pseudomonas aeruginosa cell survival within biofilms and is synergistic with antibiotic treatment
- Flamholz, Avi I.;Saccomano, Samuel et al. (2022) Optical O₂ sensors also respond to redox active molecules commonly secreted by bacteria
- Tumasyan, A.;Adam, W. et al. (2022) Search for Resonances Decaying to Three W Bosons in Proton-Proton Collisions at √s=13TeVPhysical Review Letters
- Tookmanian, Elise;Junghans, Lisa et al. (2022) Hopanoids Confer Robustness to Physicochemical Variability in the Niche of the Plant Symbiont Bradyrhizobium diazoefficiensJournal of Bacteriology
ESE/Bi 168. Microbial Metabolic Diversity.
9 units (3-0-6); second term, 2021-22.
Prerequisites: ESE 142, ESE/Bi 166.
A course on the metabolic diversity of microorganisms. Basic thermodynamic principles governing energy conservation will be discussed, with emphasis placed on photosynthesis and respiration. Students will be exposed to genetic, genomic, and biochemical techniques that can be used to elucidate the mechanisms of cellular electron transfer underlying these metabolisms. Given in alternate years; not offered 2021-2022.
Instructor: Newman
Instructor: Newman
ESE/Bi 168. Microbial Metabolic Diversity.
9 units (3-0-6); second term, 2020-21.
Prerequisites: ESE 142, ESE/Bi 166.
A course on the metabolic diversity of microorganisms. Basic thermodynamic principles governing energy conservation will be discussed, with emphasis placed on photosynthesis and respiration. Students will be exposed to genetic, genomic, and biochemical techniques that can be used to elucidate the mechanisms of cellular electron transfer underlying these metabolisms. Given in alternate years; offered 2020-21.
Instructor: Newman
Instructor: Newman